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SN-008625 ***Alert Note***

The Likelihood Ratio Test Statistic for the Marker-Trait Association in

PROC HAPLOTYPE is incorrect

Product: SAS/Genetics

Component: HAPLOTYPE procedure

Priority: ALERT

The Likelihoood Ratio Test (LRT) statistic and its associated p-value

for the Marker-Trait Association in PROC HAPLOTYPE are incorrect. The

correct Likelihood Ratio statistic can be obtained by multiplying the

value of the Chi-Square statistic that is reported by 2. The p-value

for the LRT reported in the the column "Pr>Chisq" is also incorrect.

To obtain the correct p-value, use the PROBCHI function in the DATA

STEP. The correct p-value can be calculated as:

p_value = 1 - probchi(chisq,df);

where chisq is the corrected Chi-Square statistic, and df is equal to

the sum of the degrees of freedom of each TRAIT variable, minus the

degrees of freedom reported in the row "COMBINED".

Keywords:

likelihood ratio test statistic marker trait association proc haplotype

sas genetics incorr wrong

the likelihood ratio test statistic for the marker-trait association in

proc haplotype is incorrect

008625 8625

SAS Note Revised On: Fri, 11 Oct 2002

System Version Reported Version Fixed

AIX 64 bit 8.2 TS2M0 9

AIX/6000 8.2 TS2M0 9

Compaq Tru64 UNIX 8.2 TS2M0 9

HP-UX Operating Systems 8.2 TS2M0 9

HP-UX 64 bit 8.2 TS2M0 9

Intel ABI 8.2 TS2M0 9

Solaris 8.2 TS2M0 9

Solaris 64 bit 8.2 TS2M0 9

Windows NT 8.2 TS2M0 9

No Fixes Available

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